NAD+

Peptoris Labs

NAD+

£70.00

Plan your course

Not sure of the dose? Use the figure from this product's research protocol and choose whether it is per day or per week below.

Dose Frequency Course length

— vial(s) needed at — vial size

Estimate only — based on a steady dose at your chosen frequency and selected vial size. Titration may use less in early weeks. For research use only, not medical advice.

Description

NAD+ is nicotinamide adenine dinucleotide, an essential cellular coenzyme used in redox biology and as a substrate for sirtuins, PARPs, and CD38. It is studied across metabolism, DNA repair, and cellular aging research.

Quickstart Highlights

NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme involved in cellular energy metabolism, DNA repair, and mitochondrial function[1]. Clinical research has primarily employed intravenous infusions at high doses, though subcutaneous administration at lower doses is emerging as a practical maintenance route[2][3].

Storage Instructions

Proper storage is critical to preserve NAD+ stability and potency.

  • Lyophilized (Unopened): Store at −20 °C (−4 °F) or below (ideally −80 °C for multi‑year storage) in a dry, dark environment[6]. Minimize moisture exposure as NAD+ powder is hygroscopic.
  • Reconstituted Solution: Refrigerate at 2–8 °C (35.6–46.4 °F) and use within approximately 14 days[7]. Keep protected from light (UV exposure degrades NAD+).
  • Avoid Freeze–Thaw Cycles: Do not repeatedly freeze and thaw reconstituted NAD+ solution, as this reduces potency.
  • Inspection: Before each use, inspect the solution for clarity. A fresh NAD+ solution should be clear and colorless. Discard if discoloration, cloudiness, or precipitate develops.

How It Works

NAD+ is a coenzyme central to redox reactions, energy metabolism (glycolysis, TCA cycle, oxidative phosphorylation), and cellular maintenance pathways including DNA repair and mitochondrial biogenesis[1]. Cellular NAD+ levels decline with age and metabolic stress, which may contribute to reduced mitochondrial function and impaired cellular resilience[8].

Clinical research on NAD+ therapy has primarily used intravenous infusions at high doses (500–1,000 mg) for applications such as addiction treatment and acute metabolic support[2][9]. A pilot metabolic study demonstrated that a 750 mg NAD+ IV infusion over 6 hours was well‑tolerated in humans, with rapid metabolic clearance and no acute toxicity[10]. However, IV administration requires clinical supervision and specialized equipment.

Subcutaneous (SC) or intramuscular (IM) injections at lower doses (tens to low hundreds of milligrams) are emerging as practical alternatives for maintenance therapy and wellness applications[3][11]. Compounded NAD+ can be administered SC in small volumes, and SC self‑injection is convenient for ongoing use[12]. Conservative protocols start around 50–100 mg per injection a few times per week; the present protocol uses daily SC administration with gradual titration to optimize individual tolerance and response.

Potential Benefits & Side Effects

Observations from preclinical models and clinical case reports.

Potential Benefits (Reported in Literature)

  • May support cellular energy production and mitochondrial function through replenishment of NAD+ pools[1][8].
  • Human case reports and pilot studies suggest benefits at 100–300 mg/day ranges for cognitive support and metabolic health[13].
  • High‑dose IV protocols (500–1,500 mg daily for ~10 days) have been used in open‑label studies for substance use disorder, with reports of reduced cravings and improved mood in follow‑ups[2][9].
  • No severe adverse events have been reported in published NAD+/NADH trials; side effects are generally mild[14].

Potential Side Effects

  • High doses can produce adverse reactions such as insomnia, anxiety, or fatigue if escalated too quickly; gradual titration is advised[4].
  • Mild injection‑site reactions (redness, itching, soreness) may occur with subcutaneous administration; typically resolve with site rotation.
  • Some individuals report transient headache or flushing; these effects are generally dose‑dependent.
  • Doses exceeding ~200–300 mg/day should generally be reserved for supervised therapeutic use due to potential for metabolic byproduct accumulation[15].

References

Certificate of Analysis

Every batch of NAD+ is independently lab-tested to a minimum of 98% purity. A Certificate of Analysis is available on request — contact us with your order or lot number and we'll send the COA for your specific batch.

Request a COA

Research Protocol

Full dose-by-dose reconstitution & dosing protocol for NAD+.

View Research Protocol →

For laboratory and scientific research use only. Not medical advice.

For laboratory and research use only. Minimum 98% purity. Supplied in sterile, flip-top headspace vials for laboratory use. Not intended for human or animal consumption, medical, diagnostic, therapeutic or veterinary use. These statements have not been evaluated by the MHRA or FDA. The purchaser accepts full responsibility for safe handling, storage and lawful use.