Melanotan II (MT2)

Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that triggers melanin production in skin cells. Originally developed by researchers at the University of Arizona as a potential preventive treatment for skin cancer—theorizing that increased melanin could protect against UV damage—the peptide proved highly effective at producing tans but also demonstrated unexpected effects on sexual function and appetite. This combination has made it popular among those seeking tanning without extensive sun exposure, though it remains unapproved by the FDA and carries real risks including mole changes that require monitoring. The compound works by activating melanocortin receptors throughout the body, producing its diverse effects on pigmentation, sexual arousal, and feeding behavior.