Epithalon

Epithalon (also spelled Epitalon or Epithalone) is a synthetic tetrapeptide based on the natural peptide epithalamin, which is produced by the pineal gland. Developed by Russian scientist Vladimir Khavinson over decades of research at the St. Petersburg Institute of Bioregulation and Gerontology, Epithalon has shown the ability to activate telomerase—the enzyme that maintains telomere length. Telomeres are protective caps on chromosome ends that shorten with each cell division; when they become too short, cells can no longer divide properly, contributing to aging. By activating telomerase, Epithalon may help cells maintain their telomeres and extend their replicative lifespan. Research has also shown effects on melatonin production, sleep quality, and potentially lifespan extension in animal studies.